Reproduction Abstracts

The fetus is antigenically distinct from the mother and therefore the maternal immune system must establish immunological tolerance towards the fetus to support pregnancy. Fetal-maternal tolerance is primarily mediated by a specialised subset of CD4+T cells known as regulatory T (Treg) cells. Absence or reduced function of Treg cells at embryo implantation causes infertility in mice and is implicated as a cause of reproductive disorders in women. The importance of a...