Reproduction Abstracts

Contents

• SYMPOSIA
• • Symposium 1: New technologies in reproductive science
  • • Can reproductive technologies prevent transmission of mitochondrial DNA disease?

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    • Biallelic genome editing of human stem cells at scale

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    • Monitoring dynamic changes of DNA methylation in single cells during development and disease

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  • SRF-SRB Exchange Lecture
  • • Progesterone control of regulatory T cell phenotype and abundance

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  • Symposium 2: New roles for old signalling pathways
  • • Leptin revisited: Novel neurohormonal and molecular mechanisms for the reproductive roles of leptin

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    • PI3K regulation of dormant follicle activation

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    • AMH and INSL3: 'Testicular' factors with emerging intra-ovarian roles

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  • SRF New Investigator Award Lecture
  • • Genetic and environmental determinants of male reproductive health

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  • SSR New Investigator Lecture
  • • Epigenetics of the male germline from stem cells to sperm

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  • SRF Distinguished Scientist Lecture
  • • Making a good egg

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  • Symposium 3: Risks and opportunities in wildlife reproduction
  • • Contraception in domestic animals

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    • Molecular mechanisms of reproductive disruption in fish

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    • Novel technologies in screening zoo and exotic animals

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• ORAL COMMUNICATIONS
• • Oral Communications 1: Ovary
  • • Mice with follicular premature ovarian failure at 3 months of age become a follicular by 1 year of age

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    • The effect of folic acid supplementation during the juvenile pubertal period or adulthood on gene expression in the ovary

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    • PLCz-induced Ca2+ oscillations are enhanced after germinal vesicle breakdown during mouse oocyte maturation

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    • Oocyte maturation arrest in endometriosis is caused by elevated levels of Reactive Oxygen Species and enforced via a DNA Damage Response and the Spindle Assembly Checkpoint pathway

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    • A Positive Feedback Loop between Hypoxia and miRNA-210 Augments Endothelin 2 in Human Granulosa Cells

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    • Post-partum endometritis: Its negative impact on luteal vascularisation, progesterone content and steroidogenic enzyme expression in the cow

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  • Oral Communications 2: Early Development 1
  • • Cyclical DNA methyltransferase and histone deacetylase expression across multiple timescales in the uterus of the Siberian hamster (Phodopus sungorus)

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    • Mouse blastocyst implantation in an in vitro model is promoted by early apposition with the uterine epithelium and by hyperosmolar stress

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    • A novel role of Adam 10 in tight junction formation during mouse preimplantation development

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    • Investigating of the role of Tribbles-2 protein in mammalian embryo implantation

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    • Investigating O-GlcNAcylation in an in vitro model used to mimic diabetes, and its effects on implantation

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    • Efficacy of progestogen supplementation in women undergoing assisted reproductive technology treatment: A meta-analysis

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  • SRF Post-Doctoral Prize Session
  • • Identification of novel DAZL targets in the human fetal ovary

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    • Etoposide results in follicle loss in the fetal mouse ovary, but does not block the ability of oocytes to progress through prophase I of meiosis

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    • The crosstalk between Nodal and Tumor Necrosis factor alpha during luteolysis establishment in the mare

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  • SRF Student Prize Session
  • • Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS)

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    • Derivation and use of mouse embryonic stem cell lines as model for mechanistic analysis of periconceptional developmental programming

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    • FACS-sorted putative oogonial stem cells from the mouse ovary are neither DDX4-positive nor germ cells

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    • Immune cell dynamics in endometrial repair and remodelling

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    • Maternal high fat diet (HFD) in the adult offspring brain modifies cell density and neuronal density

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    • Abstract unavailable

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  • Oral Communications 3: Environmental and programming effects on reproduction
  • • Role of miRNAs in the hypoxic regulation of human embryonic stem cells

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    • Paternal low protein diet affects fetal growth, placental development and skeletal formation in mice

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    • Maternal protein restriction around conception alters the foetal mouse brain by reducing the neural stem cells and increasing neuronal differentiation during gestation, which might be associated with the adult behavioural deficits

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    • Maternal dietary protein restriction had no adverse effect on fetal ovarian morphology and germ cell markers on day 65 of gestation in sheep

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    • Fetal androgens determine adult pancreatic function

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    • Androgen causes whitening of brown adipose tissue: Implications for PCOS

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  • Oral Communications 4: Early Development 2
  • • The effect of decidual stromal cells on immune cells in the first trimester of pregnancy

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    • The role of integrin AVB6 in the regulation of foetal growth in pigs

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    • Different mechanism of lipid accumulation in embryoblast and trophoblast cells trigger by lipid excess

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    • Ontogeny of molecular transporters in the human placenta

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    • The target organs of human placental micro- and nano-vesicles

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    • Spermbots: Magnetic microrobots that assist sperm cells on their journey, opening new routes to assisted reproduction

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• POSTER SESSIONS
• • (1)
  • • Abstract unavailable

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    • A retrospective review of outcomes following endometrial scratch procedure in IVF at Fertility Exeter

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    • Bi-directional regulation of miR-125a-3p expression by mural and cumulus granulosa cells of mice pre-ovulatory follicles

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    • The function of Histone Variants in female infertility

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    • Abstract unavailable

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    • Does Neuromedin B exert a local modulatory effect on ovarian steroidogenesis or cell proliferation?

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    • Alterations in the vasculature of placental but not endometrial tissue associated with small porcine foetuses compared to their normal-sized littermates

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    • Generation of GFP transgenic cynomolgus monkeys

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    • Involvement of MyD88 in B-cell mediated immune response in a mouse model of LPS-induced fetal death

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    • Role of micro-RNAs in thrombospondin-1 expression in bovine luteal cells

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    • Effect of lipopolysaccharide on steroidogenesis and cell migration in the bovine ovary

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    • Investigation of the relationship between HA binding and sperm function tests including sperm DNA damage and chromatin maturity

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    • Characterisation of extracellular vesicles produced by the Porcine oviductal epithelial cells using size exclusion chromatography

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    • PI3K/AKT signaling pathway involvement in motility loss associated with prohibitin downregulation in sperm from infertile men

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    • Effect of atrazine on sperm mitochondrial function, acrosome reaction and fertilization competence: The bovine model

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    • Effect of pre-in vitro maturation using PACAP on nuclear and cytoplasmic maturation in porcine cumulus-oocyte complexes derived from small follicle

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    • Treatment of GDF8 during in vitro maturation increased phosphorylated SMAD2/3 and improved in vitro fertilized embryo developmental competence

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    • Establish of a transgenic neural cell line with an astrocyte-specific inducible CreERT2 system

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    • Effect of lysophosphatidic acid (LPA) on in vitro maturation of porcine oocytes and subsequent embryonic development after parthenogensis and in vitro fertilization

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    • Effects of the chemotherapy drugs cisplatin and doxorubicin on the follicles of the human ovary

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    • Impact of a contrasted metabolism on endometrial and peripheral signalling pathways at implantation in dairy cattle

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    • Analysis of follicle development in a mouse model with increased fertility

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    • Therapeutic doses of phosphoramide mustard cause germ cell death in the prepubertal mouse testis

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    • Targeting lactate metabolism can be a novel therapeutic for the treatment of endometriosis

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    • Abstract unavailable

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    • Membrane potential contributes to generation of high amplitude [Ca2+]i oscillations and sperm behaviour in human spermatozoa

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    • Investigating the role of the membrane receptor ADGRD1 in female fertility

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    • Effect of pHi on regulation of hyperactivated motility in human spermatozoa

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    • Gonadotropins induce expression of versican in porcine oocyte-cumulus extracellular matrix and mural granulosa cells

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    • Determining the effect of extra-villous trophoblast cells on spiral artery remodelling: What is the role of MMP10?

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    • Geographical variation in canine testicular environmental chemicals: a possible link with altered reproductive development

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    • Female reproductive ageing: When during oogenesis do chromosomes begin to fall apart?

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    • Cellular modeling of citrin deficiency using human induced pluripotent stem cell-derived hepatocytes

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    • Disease takes its Toll on reproduction: Toll-like receptors and the bovine corpus luteum

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    • The impact of the selective progesterone receptor modulator (SPRM), ulipristal acetate (UPA) administration upon cell proliferation markers within the human endometrium

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    • Mouse follicles have a smaller follicular antrum in the absence of oocyte core 1-derived O-glycans at two weeks of age

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    • SIRT1 regulates low oxygen induced bovine granulosa cell proliferation through interaction with VEGF-AKT-mTOR pathway

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    • Abstract unavailable

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    • Comparative investigation of lipid peroxidation and antioxidant enzymes in relation to semen quality

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    • Pup sex and body mass of rats raised in different lactation litter sizes affect ghrelin and peptide-YY concentrations

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    • Effect of aflatoxin B1, on sperm vitality, mitochondrial function and acrosome reaction: the bovine model

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    • A Bayesian view of rodent seminal cytokine networks

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    • Dynamic changes in expression and DNA methylation of the astrocyte-specific genes Slc1a2 and Lrg1 during development: implications for preterm birth?

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    • Germ cells, from a mouse model of Premature Ovarian Failure, retain the potential to support follicle development when reaggregated with wildtype somatic cells

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    • Effect of temperature on bovine granulosa cells cultured under low oxygen in the presence or absence of melatonin

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    • PGF2alpha regulates the expression of genes involved in embryo-maternal interactions in the porcine endometrium and conceptus cells

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    • The effect of macrophage colony-stimulating factor (CSF1) on piglet gonad development

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    • Histological categorization of equine ovarian follicles from healthy and diseased mares

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    • The effect of dietary protein level on bovine follicular dynamics in beef heifers

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    • Inhibition of macrophage colony-stimulating factor-1 (CSF-1) receptor signalling: a novel therapeutic target for tubal ectopic pregnancy

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    • Putative role for progesterone in Monodelphis domestica embryogenesis and pregnancy

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    • Male infertility-linked point mutation dramatically reduces the Ca2+ oscillation-inducing activity of sperm PLCzeta without affecting its ability to hydrolyse PIP2

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    • Antigen unmasking improves visualisation efficacy of phospholipase C zeta (PLCζ) in mammalian sperm to enable diagnostic applicability for evaluating PLCζ-dependent human oocyte activation deficiency

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    • The effect of transforming growth factor B on luteal angiogenesis and function in vitro

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    • Insight into the molecular mechanisms underlying enhanced gonadotropin hormone receptor activity in polycystic ovarian syndrome

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    • Effect of in vitro fertilization (IVF) and embryo culture duration on mouse development and postnatal health

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    • Altered expression of genes affecting oestrogen metabolism and action in granulosa-lutein cells of women with PCOS

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    • Abstract unavailable

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    • Preantral follicle development in cultured reaggregated neonatal ovaries

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    • First evidence of a menstruating rodent: the spiny mouse (Acomys cahirinus)

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