Reproduction Abstracts

Disruptions during epigenetic reprogramming in developing germ cells may result in the introduction of germline epimutations. These epimutations may cause aberrant gene expression in the developing germline and in the parent’s offspring. This project investigates the impacts of functionally depleting the essential epigenetic modifier polycomb repressive complex 2 (PRC2) on germline formation and development in the next generation. To achieve this we are examining a mouse ...