Reproduction Abstracts

Introduction: We recently demonstrated that somatic follicular cells finely regulate the translation of stored mRNAs during oocyte maturation. Amphiregulin and other EGF-like peptides expressed by follicular cells trigger the translation of specific transcripts in the oocyte, seemingly by indirect activation of the Phosphatidyl-inositol-3-kinase PI3K/AKT/mTOR cascade. The present study aims to better characterize the role of PI3K/AKT during oocyte maturation by using a genetic...