Reproduction Abstracts

Introduction: Genome-wide demethylation reprograms the genome after fertilization and re-establishes totipotency: 5-methylcytosine (5 mC) in the paternal pronucleus is rapidly converted to 5-hydroxymethylcytosine (5 hmC) by the dioxygenase 10–11 translocation (TET) 3, while 5 mC in the maternal pronucleus is protected by the binding of developmental pluripotency-associated (DPPA) 3 to histone H3 dimethyl Lys9 (H3K9me2). This process is essential for normal development, be...