Reproduction Abstracts

Introduction: The condition of primary ovarian insufficiency (POI) affects 1% of women worldwide under the age of 40, and is associated with premature ovarian follicle depletion. TAF4b is a gonadal-enriched TFIID subunit that promotes healthy ovarian aging and fertility. Female TAF4b-deficient mice experience POI hallmarks including infertility, poor oocyte quality, and dramatic gene expression changes. Understanding TAF4b’s role in promoting healthy ovarian aging is crit...