Reproduction Abstracts

Introduction: Decidual macrophages constitute the second largest leukocyte cell type in the decidua during early pregnancy, and have been implicated in the regulation of extravillous trophoblast (EVT) invasion. Macrophage cells in the decidua are thought to have an anti-inflammatory M2 phenotype and the presence of macrophages with a more pro-inflammatory M1 phenotype has been associated with preeclampsia. The aim of this study was to determine whether decidual macrophage pola...

Human pregnancy represents a unique immunological environment. However, very little is known about the role of uterine decidual macrophages (dMs) in early human pregnancy. The monocytic cell line (THP1) was activated and polarised to a pro-inflammatory M1 or immunosuppressive M2 M phenotype and the conditioned media was used to treat fetally-derived trophoblast cells. Treatment with M1 conditioned media was found to significantly reduce trophoblast motility in vitro, ...