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ra0003o024 | Oral Communications 3: Environmental and programming effects on reproduction | SRF2016

Maternal protein restriction around conception alters the foetal mouse brain by reducing the neural stem cells and increasing neuronal differentiation during gestation, which might be associated with the adult behavioural deficits

Gould Joanna , Pearson-Farr Jenny , Airey Chris , Semmence Oliver , Gould Philippa , Willaime-Morawek Sandrine , Fleming Tom

Introduction: Maternal malnutrition during pregnancy is detrimental to fetal development and increases the risk of many chronic diseases in later life i.e. neurological consequences such as increased risk of schizophrenia. Previous studies have shown maternal protein malnutrition during pregnancy and lactation compromises brain development in late gestation and after birth, affecting structural, biochemical and pathway dynamics with lasting consequences for motor and cognitive...

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Maternal protein restriction around conception alters the foetal mouse brain by reducing the neural stem cells and increasing neuronal differentiation during gestation, which might be associated with the adult behavioural deficits

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