Reproduction Abstracts

Introduction: Maternal plasma in many pre-eclamptic (PE) pregnancies is low in the placenta product “Placental growth factor” (PGF). Offspring of PE compared to uncomplicated pregnancies show higher blood pressure, cognitive impairment and stroke; mechanisms explaining these differences are undefined. In Pgf−/− mice, decidual vessels have limited branching and connectivity. We asked if PGF deficiency diminishes brain vascular developme...