Reproduction Abstracts

Introduction: Testicular germ cell cancer (TGCC) has been increasing in incidence over recent decades. We have previously shown that the precursor lesion for TGCC, carcinoma in situ (CIS) cells, have different phenotypes which determine proliferation rate. CIS which express only OCT4, a well-established marker for CIS, proliferate more that those expressing OCT4 and MAGE-A4 (differentiated germ cells marker). Gankyrin is an oncogene that interacts with MAGE-A4 and sup...