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ra0001p353 | (1) | WCRB2014

Effects of common FSH receptor single-nucleotide polymorphisms on the follicular fluid hormone profile and the granulosa cell gene expression in human small antral follicles

Borgbo Tanni , Kluckova Hana , MacEk Milan , Chrudimska Jana , Jeppesen Janni V , Lindgren Ida , Giwercman Yvonne Lundberg , Hansen Lise Lotte , Andersen Claus Yding

Background: FSH is one of the key hormones of mammalian reproduction. FSH signaling may be affected by single-nucleotide polymorphisms residing in the FSH receptor (FSHR) gene. The most pronounced effects of these polymorphisms are likely to be displayed in the follicle fluid, which acts as a reservoir for granulosa cell secreted hormones induced by FSH.Methods: Genetic polymorphisms of FSHR in position -29 (FSHR -29) and in codon 307 and codon ...

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Effects of common FSH receptor single-nucleotide polymorphisms on the follicular fluid hormone profile and the granulosa cell gene expression in human small antral follicles

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