Reproduction Abstracts

Introduction: Forkhead box protein N1 (FoxN1) regulates development, differentiation, and function of thymus epithelial cells (TECs), both in the prenatal and postnatal thymus. In mice, knockout of the FoxN1 results in two well-known defects as hairlessness and athymia. However, knockout of FoxN1 in other species has not been discovered yet. RNA-guided endonucleases (RGENs), derived from the prokaryotic type II CRISPR-Cas system, enable targeted specific genes. We successfully...