Reproduction Abstracts

Introduction: A sucessful implantation depends on the exquisite coordination between embryo and maternal uterus. N-myc downregulated gene 2 (NDRG2) belongs to the NDRG gene family, a new class of Myc-repressed genes, and possesses tumor suppression function. Given the similarities between embryo implantation and the growth of cancer cell, the present study was undertaken to examine the expression and regulation of NDRG2 during peri-implantation period.Ma...

Introduction: Immune tolerance at the feto–maternal interface must be established during the processes of implantation and pregnancy. Monoclonal nonspecific suppressor factor beta (MNSFβ) is a secreted protein that possesses antigen-nonspecific immune suppressive function. The objective of this study was to establish the MNSFβ gene knockout mouse model, observe and analyze its reproductive phenotypes to further explore the roles of MNSFβ played in mouse emb...

Introduction: Encoding an 88 kDa protein with a thioredoxin-like domain at the N-terminal region, ssp411 is predominantly expressed at several specific stages from round spermatids to spermatozoa in the rat testis at both mRNA and protein levels. SSP411 is conserved in many species, and can be localized in the testis and mature sperm of human, mouse, and rat.Materials and methods: A line of ssp411 knockout mice (ssp411&#87...

Background: The role of autoantibodies against zona pellucida (ZP) in infertility and success of IVF is debatable. In the present study, a novel recombinant human zona protein is used to address this issue.Materials and methods: Fourteen serum samples positive for porcine ZP, six from infertile patients, and 20 from healthy women were analysed. Sera were tested for their reactivity against a recombinant multi-epitope peptide (named ZPCP7) composed of ten...