Reproduction Abstracts

Introduction: The production of functional spermatozoa is a highly complex process that requires tight regulation of gene expression. Pre-mRNA splicing is an essential post-transcriptional process. Over 95% of multi-exon human genes undergo alternative splicing to create diverse arrays of mRNAs from a single gene. Disturbance of splicing regulation is associated with many human diseases.Materials and methods: A genome-wide ENU mutagenesis screen was carr...