Reproduction Abstracts

Introduction: While gonadotoxicity of cyclophosphamide (Cy) has been well demonstrated in mice model, the kinetic and effect at different follicular stages are still not well described. Understanding these phenomena is however essential to further develop pharmacological protective approaches. Here, we studied the effect of Cy at different doses and timing on follicular development as well as the potential gonadoprotective effect of the GnRH analogues (GnRHa) during chemothera...