Reproduction Abstracts

The ‘old’ science base generally casts androgens as ‘bad’ for folliculogenesis: agents of follicular atresia and directly involved in reproductive pathologies such as PCOS. A more recent literature has mapped cellular sites of androgen formation and action within the ovarian follicle, pinpointing theca as the source and granulosa its target. Molecular studies have located the androgen receptor (AR) to granulosa cells, functionally coupled to FSH-regulated (...