ra0001p221 | (1) | WCRB2014
Olcorn Justine Samantha
, Rainczuk Katarzyna Eliza
, Foo Caroline
, Haverfield Jenna T
, Stanton Peter G
Introduction: The blood–testis barrier (BTB) remains semi-permeable to tracers of increasing molecular weight in an adult rat model of spermatogenic re-initiation. Complete closure of the BTB occurred when steps 2–7 round spermatids re-appeared in the epithelium, and coincided with the localisation of a new tight junction (TJ) protein claudin-12 (Cldn12) at the BTB. We hypothesise that meiotic and/or post-meiotic germ cells up-regulate Sertoli cell TJs, and aim to de...