Reproduction Abstracts

It has been proven that treatment of cloned embryos with a histone deacetylase inhibitor (HDACi) such as trichostatin A (TSA) following somatic-cell nuclear transfer (SCNT), significantly improves subsequent development to a blastocyst as well as full-term development (Kishigami et al. BBRC 2006). Recently, we have shown that lysine acetylation levels in both the nucleus and cytoplasm are significantly increased after oocyte activation (Matsubara et al.</...