Reproduction Abstracts

High mobility group box protein 1 (HMGB1) plays an important role in onset and progression of autoimmune diseases. This nucleosomal protein is actively secreted during inflammation and acts as a late phase cytokine. Targeting HMGB1 by ethyl pyruvate (EP) significantly reduces its pro-inflammatory effects. Experimental autoimmune orchitis (EAO) serves as a rodent model to study autoimmune based chronic testicular inflammation characterized by elevated levels of pro-inflammatory...