Reproduction Abstracts

GATA4 is a transcription factor required for testicular differentiation and for male fertility. In spite of its crucial roles in male reproduction, how the activity of this factor is regulated has yet to be fully understood. The GATA4 protein is phosphorylated on at least two serine residues. This includes GATA4 S105, which has been reported to modulate GATA4 transcriptional activity in cell line studies. Its contribution to endogenous GATA4 activity in the testis, however, ha...