Reproduction Abstracts

Introduction: FGF2 and thrombospondin-1 (THBS1) expression in corpus luteum (CL) exhibited the most divergent profile of induction by prostaglandin F2a (PGF2α). FGF2, a potent angiogenic pro-survival factor was increased in the Day 4 CL. In contrast, the anti-angiogenic, apoptotic factors, THBS1, transforming growth factor beta 1 (TGFB1) and plasminogen activator inhibitor-1 (PAI-1) were upregulated specifically on Day 11, PGF2α-responsive CL. Functionally, THBS1 rev...