ra0001p078 | (1) | WCRB2014
Kamoshita Maki
, Kato Tsubasa
, Sagara Eri
, Hisamatsu S
, Sakaue M
, Sakuma Tetsushi
, Yamamoto Takashi
, Ito Junya
, Kashiwazaki Naomi
Although GH receptor (GHR) gene deletion causes a hereditary dwarfism and also shows a longer lifespan, the fact was shown only in mice. Because it was difficult to generate knockout (KO) animals other than mice. Recently, the generation of KO animals became possible without difficulty due to advances in genome editing technologies such as transcription activator-like effector nuclease (TALEN). In the present study, we examined the effect of cRNA concentration microinjected cy...