Abstract Search

ra0001p222 | (1) | WCRB2014

The RNA-binding protein Musashi-2 (MSI2) controls mRNA processing and translational regulation via interactions with SFPQ and PIWIL1 during mammalian spermatogenesis

Sutherland Jessie M , Sobinoff Alexander P , Redgrove Kate , Davidson Tara-Lynne , Siddall Nicole A , Koopman Peter , Hime Gary R , McLaughlin Eileen

Introduction: RNA-binding proteins (RBP) are important catalysts of post-transcriptional gene regulation. The RBP MSI2 directs stem cell function and division through established roles in cell cycle dynamics and cell fate determination. During the complex process of mammalian spermatogenesis, the directed uncoupling of transcription and translation is essential for the correct development of male gametes. We have previously established that dysregulation of MSI2 during germ ce...

Reproduction Abstracts

The RNA-binding protein Musashi-2 (MSI2) controls mRNA processing and translational regulation via interactions with SFPQ and PIWIL1 during mammalian spermatogenesis

BiosciAbstracts