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ra0001p008 | Uterus | WCRB2014

Conditional deletion of progesterone receptor membrane component 1 (Pgrmc1) and Pgrmc2 results in subfertility and aberrant endometrial epithelial cell proliferation

Pru James K , Clark Nicole C , Pru Cindy A , McCallum Melissa L , DeMayo Francesco J , Lydon John P , Peluso John J

Introduction: Since progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 are highly expressed in the uterus, this study was designed to evaluate the impact of Pgrmc2 and Pgrmc1/2 deficiency on female fertility and uterine epithelial cell proliferation.Materials and methods: Uterine PGRMC2 and Ki67 expression were assessed by immunohistochemistry. Mutagenesis studies were completed in which Pgr-cre was used to conditio...

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Conditional deletion of progesterone receptor membrane component 1 (Pgrmc1) and Pgrmc2 results in subfertility and aberrant endometrial epithelial cell proliferation

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