Reproduction Abstracts

Continual spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is comprised of stem cell and progenitor fractions. Self-renewal by spermatogonial stem cells (SSCs) maintains a foundational pool from which progenitor spermatogonia arise that transiently amplify in number before committing to a pathway of terminal differentiation. At present, molecular features that distinguish the stem cell state in mammalian spermatogonia are undefined. I...