Reproduction Abstracts

Oct4 and Nanog are the transcription factors responsible for pluripotency maintenance in embryonic stem cells (ESCs), and activation of these genes in differentiated cells is considered the earliest signal of nuclear reprogramming. To date, nuclear reprogramming in somatic cells can be induced by nuclear transfer, induced expression of defined factors (Oct4, c-myc, Sox-2, and Kfl4) and, more recently, by a short exposure to a low pH. However, work in salamander as well as in p...