Reproduction Abstracts

Contents

• SYMPOSIA
• • Symposia 1: The sperm race
  • • Occupational and environmental influences on semen quality

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    • How sperm spot the egg: chemosensation in sea urchin and human sperm

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    • Gamete interactions in the female reproductive tract: it is not a race!

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  • SRF-SRB Exchange Lecture
  • • SRF-SRB Exchange Lecture: Musashi RNA binding protein MSI2 interacts with SFPQ and controls the expression of target mRNAs Tbx1 and Piwil1 in male germ cells during spermatogenesis

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  • Symposia 2: Surgical intervention and fertility
  • • Ovarian autografts and autotransplants as experimental and translational models for the treatment of infertility

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    • Uterus transplantation: an update

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    • Mechanical injury of the endometrium to enhance implantation: mechanism of action

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  • SRF New Investigator Award lecture
  • • Molecular mechanisms regulating early equine placental development in health and disease

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  • SSR New Investigator Lecture
  • • Epithelial genes in the endometrial and ovarian cancer

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  • SRF Distinguished Scientist Lecture
  • • Reproduction as the pivot for adaptability of the next generation(s), and its health consequences

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  • Symposia 3: Management of livestock fertility
  • • Nutritional impacts on fetal development: examples from ovine adolescent models

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    • Impact of prenatal stress on reproductive development in livestock

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    • Embryo-uterine dialogue in the cow

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• ORAL COMMUNICATIONS
• • SRF Post Doctoral Prize Session
  • • Hyperandrogenism modulates adipokine gene expression in mouse adipocytes: implications for PCOS

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    • Hyperphagia of pregnancy and lactation is associated with changes in appetite-regulating gut hormones and gastrointestinal modifications in Wistar rats

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    • Kinetic, morphological, and functional details of the early stages of human and mouse embryo implantation in an in vitro model

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  • Oral Communications 1: Embryo and Implantation
  • • The bioenergetic profile of the bovine blastocyst

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    • Effect of environmental oxygen on the expression of miRNAs in human embryonic stem cells

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    • Mechanism of microRNA lethal-7 in embryo dormancy in mice

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    • A potential co-culture system of ovine blastocyst with uterine endometrium to mimic initial attachment of embryo implantation

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    • The effect of IVF and embryo culture on mouse development and adult health

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  • Oral Communications 2: Ovarian function
  • • Role of KIT ligand in nuclear maturation in bovine oocytes

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    • Role of Wnt/[beta]-catenin signal transduction pathway in rat follicular development and luteal function

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    • The role of the oocyte is investigated in premature ovarian failure using the reaggregated ovarian pellet technique

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    • Differential effects of transforming growth factor beta 2 in two different models of preantral follicle growth

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    • The oocyte induces estrus stage-specific changes in theca cells and their extracellular matrix

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  • SRF Student Prize Session
  • • Maternal protein restriction around conception reduces the neural stem cells during mouse fetal brain development and alters neuronal differentiation during gestation

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    • Defective decidualisation: a possible mechanism of Chlamydia trachomatis induced miscarriage

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    • Investigating a role for the epidermal growth factor receptor in androgen signalling within mouse preantral follicle development

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    • Decidual macrophages become increasingly immunosuppressive during early pregnancy and an altered activation state may be associated with a higher risk of preeclampsia

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    • Variations in the way UK pregnant sheep are managed programs male reproductive development

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    • Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure

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  • Oral Communications 3: Sperm
  • • Sertoli-specific ablation of RHOX8 results in impaired spermatogenesis in mice

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    • Ruminal acidosis has long-term effects upon sperm production in the bull

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    • Interaction of progesterone and pH in regulation of hyperactivated motility in human spermatozoa

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    • Notch signaling in the bovine oviduct and spermatozoa: a regulator of the spermatozoa-oviduct interaction?

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    • The effects of alcohol-induced oxidative stress on sperm DNA and fertility outcomes

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  • Oral Communications 4: Female reproduction
  • • Alteration of mechanisms underlying pituitary microvasculature remodelling and reduction in prolactin secretion precede full activation of the gonadotrophic axis in anoestrous ewes receiving exogenous melatonin

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    • Neuroendocrine control of ovulation in primates: a role for two distinct populations of GnRH neurons?

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    • Investigation into the role of endometrial heparinase, hypoxia-inducible factor 1A, secreted phosphoprotein 1, uteroferrin, and vascular endothelial growth factor A in foetal growth in pigs

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    • Regulation of the prostaglandin synthase COX2 by epidermal growth factor requires steroid receptor coactivator interacting protein in human myometrium

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    • Maternal leptin levels: association with pregnancy outcome

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• POSTER PRESENTATIONS
• • (1)
  • • Sperm preparation technique affects functional motility in human sperm

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    • Associations between circulating non-esterified fatty acids and uterine function in postpartum dairy cows

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    • Characterization of migratory and gonadal porcine PGCs

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    • Effect of macrophages on steroidogenesis and cell migration in bovine ovaries

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    • A deep RNA sequencing study of mammalian sperm RNA: identifying common cross-species expression motifs indicating functionality

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    • Endometrial level of lysophosphatidic acid (LPA) and expression of LPA receptors mRNA in endometrosis in the mare

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    • Effect of hyaluronan on some molecular markers of implantation in sheep endometrial cells in vitro

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    • Expression of porcine CXADR and its role in blastocyst formation

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    • A model of tissue-engineered (3d) decidua to study the effects of environmental pollutants on endometrial physiology

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    • Characterisation of the dog as a sentinel species for human exposure to endocrine disrupting chemicals

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    • Assessment of major reproductive problems and reproductive status of crossbred (Holstein Friesian X Zebu) dairy cattle in and around Mekelle, Tigray, Ethiopia

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    • Expression and possible role of receptor-interacting protein kinase (RIPK) 1 and 3 in the bovine CL

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    • Whether equine Corpus Luteum is a site for LPA synthesis and/or a target for LPA action?

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    • The effect of E.coli lipopolysaccharide (LPS) on bovine luteal endothelial cell network formation and steroidogenesis in vitro

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    • The association between uterine disease and subsequent reproductive performance in commercial UK dairy herds

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    • Membrane potential is crucial for one of the [Ca2+]i oscillations profiles induced by progesterone in human spermatozoa

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    • Differential proteomic profiles of porcine follicular fluid associated with a high fibre diet and later fertility

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    • An E4BP4 knockout model to assess the distribution of uterine Natural Killer cell subsets in mouse pregnancy

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    • PCR detection and phylogenetic analysis of bovine herpesvirus 4 field-isolates from dairy cows in Thailand

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    • The effect of oocyte-specific ablation of N- and O-glycans on the cumulus extracellular matrix

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    • Inter-generational effect of maternal analgesic exposure on female ovaries of second generation of female rats

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    • Role of sperm thiols? redox status in keeping rat sperm quiescent in cauda epididymis

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    • The effects of environmental chemicals on bovine luteal function

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    • Ovarian transcriptome profile before, during and after the onset of premature ovarian failure in a mouse with oocyte-specific deletion of Mgat1 and Cgalt1 genes

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    • CG9879 in the Drosophila testis

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    • Regulation of expression of oocyte quality control factor, ATRX, in bovine oocytes during maturation

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    • Dynamics of hyaluronic acid (hyaluronan) binding proteins in relation to sperm capacitation and the acrosome reaction

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    • Expression of coxsackie virus and adenovirus receptor (CXDAR) affects tight junction complex ADN cell lineage in mouse blastocyst

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    • Successful isolation, culture and karyotyping of equine placental cells from failed early pregnancies

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    • The endocrine disrupting chemicals bisphenol A, dichlorodiphenyltrichloroethane (DDT), methoxyclor and ethinylestradiol modulate thecal steroidogenesis in vitro

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    • Does maternal progesterone supplementation in early pregnancy affect fetal development?

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    • PGF2[alpha]-PTGFR signaling promotes angiogenesis in the porcine endometrium during early pregnancy

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    • Functional evaluation of miRNAs during the ovarian follicular/luteal transition

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    • Effect of cryopreservation on follicular development in human ovarian tissue

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    • Differential gene expression in granulosa-lutein cells from women with polycystic ovaries is independent of the dose of FSH given for ovarian stimulation

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    • Effects of maternal peri-conception and first trimester protein supplementation on circulating progesterone levels and concomitant conception rates in yearling heifers

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    • In vitro culture of IVM derived porcine embryos: comparisons of single-step and sequential media systems on embryo quality and cryosurvivability

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    • Experimental models for challenging the 'KNDy hypothesis': the acute response of GnRH secretion to nutrition

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    • Abstract unavailable

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    • Sex specific effects of maternal dietary protein during the periconceptional period upon hepatic gene expression in heifer progeny

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    • Regulation of CyclinD2 by Smad3 and Foxl2 during early follicle development

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    • Genome-wide cDNA microarray screening to correlate gene expression profiles of aged mouse ovary to the size of the reserve of the primordial follicle

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    • Melatonin-induced regulation of vascular endothelial growth factor (VEGF) isoform expression and microvasculature remodelling in the pituitary gland of seasonally anoestrous ewes

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    • Melatonin regulates seasonal variations in prolactin and follicle stimulating hormone synthesis via alternative splicing of pituitary vascular endothelial growth factor-A

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    • Periovulatory oxygen levels within the porcine oviduct obtained by laparoendoscopic single-site surgery

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    • Effect of Rhodobacter sphaeroides LPS on toll-like receptor 4 in bovine endometrial cells

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    • Waddlia chondrophila stimulates CXCL8 expression in ruminant trophoblast cells via p38 and p42/44 MAPK dependent pathways

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    • The effect of prenatal exposure to androgen and to a high fat diet on obesity in female mice

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    • Does kisspeptin exert a local modulatory effect on ovarian steroidogenesis?

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    • Immunohistochemical detection of hypoxya markers in the porcine oviduct

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    • SPRASA knockout mice are sub-fertile

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    • The effect of reproductive ageing on chromatin configuration and amino acid metabolism in germinal vesicle staged sheep oocytes in vitro

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    • Investigating the action of 1,25(OH)2D3/vitamin D3 in the human ovary: relevance to fertility and polycystic ovary syndrome (PCOS)

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    • Characteristics of bovine granulosa cells cultured under low and high oxygen tensions in the presence of different concentrations of melatonin

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    • Impact of maternal age on oocyte amino acid turnover and mitochondria DNA copy number in sheep

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    • Serine/threonine kinase receptor associated protein (Strap) inhibits early follicle development in mouse ovaries

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