ra0001s001 | SRF Plenary Lecture | WCRB2014
Franks Stephen
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility but typically is also associated with insulin resistance, disordered energy balance and a predisposition to develop type 2 diabetes mellitus. Anovulation is characterised by arrest of antral follicles but there is compelling evidence for disordered regulation of the early stages of preantral follicle development in the ovaries of women with PCOS. Dysregulation of local growth factor function a...