WCRB2014 POSTER PRESENTATIONS (1) (335 abstracts)
Effects of early exposure to bisphenol A, indole-3-carbinol, and/or genistein and the prostatic development in male rats offspring
Joyce Zalotti Brandt 1 , Cristiane Figueiredo Pinho 1 , Lívia Teresa Ribeiro Silveira 1 , Paulo César Georgete 2 , José Eduardo Bozano 1 , Luis Fernando Barbisan 1 & Wellerson Rodrigo Scarano 1
1Institute of Biosciences, Sao Paulo State University, UNESP, Botucatu, Brazil; 2School of Medicine, UNESP, Botucatu, Brazil.
Bisphenol A (BPA) has been investigated for its potential carcinogenic activity for prostate. Studies have shown that indole-3-carbinol (I3C) and genistein (GEN) can activate antiproliferative and proapoptotic signaling pathways. The aim of this study was evaluate the influence of I3C (20 mg/kg) and GEN (5 mg/kg) on the development of prostate of offspring rats exposed during gestation and lactation to BPA (10 mg/kg). Pregnant female Sprague–Dawley rats were divided into five groups: G1: control; G2: BPA; G3: BPA+GEN; G4: BPA+I3C+GEN; and G5: BPA+I3C. All treatments were performed by gavage from gestational day 17 until postnatal day 21. After weaning, ten male rats/group were euthanized by decapitation. Histological sections of the ventral prostate were stained with H&E, picrossírius, reticulin, and the collagen content was quantified by LeicaWin Software. The prostate histological analysis showed numerous small acini with open and regular lumen and less crimped in G1 and G2. The groups G3 to G5 exhibited acinar epithelium more folded than G1 and G2. The acini epithelium showed to be predominantly high single cylindrical cells and delicate fibromuscular stroma. Reticular fibers were thin and continuous and surround the prostatic acini, delimiting basically the basal membrane of epithelial cells. The collagen content was significantly higher in G2 when compared to the other groups, while the G5 group showed reduction when compared to G1, as well as G4 in relation to G3 respectively. The proportion of immunoreactive epithelial cells to androgen receptor (AR) decreased significantly in G5 compared to G1 and G2. BPA exposure influenced the normal prostate development, and I3C appears to reduce partially their effects.
Article tools
My recent searches
My recently viewed abstracts
Authors
Reproduction Abstracts
ISSN 2052-1472 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more